{"id":5539,"date":"2022-05-10T02:01:47","date_gmt":"2022-05-09T18:01:47","guid":{"rendered":"https:\/\/amdl.com.hk\/?page_id=5539"},"modified":"2022-07-24T19:07:57","modified_gmt":"2022-07-24T11:07:57","slug":"onco-reveal-lung-and-colon-cancer-genetic-test","status":"publish","type":"page","link":"https:\/\/amdl.com.hk\/zh\/onco-reveal-lung-and-colon-cancer-genetic-test\/","title":{"rendered":"ONCO\/Reveal\u2122 Lung and Colon Cancer Genetic Test"},"content":{"rendered":"
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ONCO\/Reveal\u2122
Lung and Colon Cancer Genetic Test<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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What is Lung and Colon Cancer Genetic Test?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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It detects numerous gene regions of interest for researchers looking to explore the genetic sequences of both germline and formalin-fixed paraffin-embedded (FFPE) DNA from lung cancer and colon cancer samples. Utilizing SLIMamp®<\/sup> (stem-loop inhibition mediated amplification) allows researchers to amplify regions of interest in a simple, multiplex reaction for subsequent sequencing on a sequencer using a paired-end read length of 150 (2×150).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u5927\u591a\u6578\u7684\u80ba\u764c (~85%) \u90fd\u6b78\u985e\u70ba\u975e\u5c0f\u7d30\u80de\u80ba\u764c (NSCLC)\u3002[4] <\/sup>\u8fd1\u4e00\u534a\u7684 NSCLC \u75c5\u4f8b\u8207\u9ede\u7a81\u8b8a\u6216 EGFR \u7b49\u5176\u4ed6\u751f\u7269\u6a19\u8a18\u6709\u95dc\u3002\u9019\u4e9b\u751f\u7269\u6a19\u8a8c\u7269\u7684\u6d41\u884c\u7387\u56e0\u7a2e\u65cf\u800c\u7570\u3002\u4e9e\u6d32 NSCLC \u60a3\u8005\u7684 EGFR \u57fa\u56e0\u7a81\u8b8a\u6bd4\u4f8b (30-40%) \u9060\u9ad8\u65bc\u7f8e\u570b\u548c\u6b50\u6d32\u7684 NSCLC \u60a3\u8005 (10-15%)\u3002[1]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\"\"<\/figure>

non-small cell lung cancer (NSCLC)<\/h3>

85%<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\"\"<\/figure>

35-40% of patients with CRC found activating mutations in KRAS<\/h3>

10-15%<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\"\"<\/figure>

The proportion of EGFR mutations<\/h3>

30-40%<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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[1] Ellison, G., Zhu, G., Moulis, A., Dearden, S., Speake, G., & McCormack, R. (2012). EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples. Journal of Clinical Pathology, 66<\/em>(2), 79\u201389. https:\/\/doi.org\/10.1136\/jclinpath-2012-201194<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\u5927\u7d04\u6709 35-40% \u7684 CRC \u60a3\u8005\u767c\u73fe KRAS \u6709\u6d3b\u5316\u7a81\u8b8a\u3002\u56e0\u6b64\uff0cKRAS \u57fa\u56e0\u7a81\u8b8a\u72c0\u614b\u53ef\u4f5c\u70ba\u6297 EGFR \u9776\u5411\u6cbb\u7642\u53cd\u61c9\u7684\u9810\u6e2c\u751f\u7269\u6a19\u8a18\u3002\u76ee\u524d\u5df2\u6709\u6709\u529b\u8b49\u64da\u986f\u793a\uff0c\u897f\u59a5\u6614\u55ae\u6297 (cetuximab) \u548c\u5e15\u5c3c\u59a5\u55ae\u6297 (panitumumab) \u5c0d\u816b\u7624\u5e36\u6709\u91ce\u751f\u578b KRAS \u57fa\u56e0\u7684 CRC \u60a3\u8005\u6709\u6548\u3002 [2]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\"\"<\/figure>

Patients with CRC found activating mutations in KRAS<\/h3>

35-40%<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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[1] Ellison, G., Zhu, G., Moulis, A., Dearden, S., Speake, G., & McCormack, R. (2012). EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples. Journal of Clinical Pathology, 66<\/em>(2), 79\u201389. https:\/\/doi.org\/10.1136\/jclinpath-2012-201194<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\u76ee\u6a19 \n\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Researchers looking to explore the genetic sequences of both germline and formalin-fixed Paraffin-embedded (FFPE) DNA from lung cancer and colon cancer samples.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Table 1. Gene List<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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AKT1<\/td>\n\t\t\tEGFR<\/td>\n\t\t\tFGFR2<\/td>\n\t\t\tNOTCH<\/td>\n\t\t\tSTK11<\/td>\n\t\t<\/tr>\n\t\t
ALK<\/td>\n\t\t\tERBB2<\/td>\n\t\t\tFGFR3<\/td>\n\t\t\tNRAS<\/td>\n\t\t\tTP53<\/td>\n\t\t<\/tr>\n\t\t
BRAF<\/td>\n\t\t\tERBB4<\/td>\n\t\t\tKRAS<\/td>\n\t\t\tPIK3CA<\/td>\n\t\t\t <\/td>\n\t\t<\/tr>\n\t\t
CTNNB1<\/td>\n\t\t\tFBXW7<\/td>\n\t\t\tMAP2K1<\/td>\n\t\t\tPTEN<\/td>\n\t\t\t <\/td>\n\t\t<\/tr>\n\t\t
DDR2<\/td>\n\t\t\tFGFR1<\/td>\n\t\t\tMET<\/td>\n\t\t\tSMAD4<\/td>\n\t\t\t <\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\u9805\u76ee <\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/th>\n\t\t\t\t\t\t\t\t\t\t\t
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Lung and Colon Cancer Genetic Test<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/th>\n\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t<\/thead>\n\n\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tContent\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t22 genes related to NSCLC and CRC tumour (please refer to table 1 for details)\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tSequencing Platform\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tNGS \t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tSequencing Type\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tAmplicon based sequencing \t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tVariants Type\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tSNVs, indel\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tSample Type\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tFFPE\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\tTAT\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t7 working days**\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t\t\t\t\t<\/tbody>\n\t\t<\/table>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\u6d41\u7a0b<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tSTEP 01<\/span>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t
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<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tSTEP 01<\/span>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t

\u552e\u524d\u8aee\u8a62 <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tSTEP 02<\/span>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t
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<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tSTEP 02<\/span>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t

\u7c3d\u7f72\u540c\u610f\u66f8\u3001\u6536\u96c6\u798f\u723e\u99ac\u6797\u56fa\u5b9a\u77f3\u881f\u5305\u57cb(FFPE) \u816b\u7624\u7d44\u7e54\u584a<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t
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**Only applicable to the sample that fulfil the QC requirements.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

ONCO\/Reveal\u2122 Lung and Colon Cancer Genetic Test What is Lung and Colon Cancer Genetic Test? It detects numerous gene regions of interest for researchers looking to explore the genetic sequences of both germline and formalin-fixed paraffin-embedded (FFPE) DNA from lung cancer and colon cancer samples. Utilizing SLIMamp® (stem-loop inhibition mediated amplification) allows researchers to amplify regions of interest in a simple, multiplex reaction for subsequent sequencing on a sequencer using a paired-end read length of 150 (2×150). The majority of lung cancers (~85%) are classified as non-small cell lung cancer (NSCLC).[4] Nearly half of NSCLC cases are associated with point […]<\/p>","protected":false},"author":214404990,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-5539","page","type-page","status-publish","hentry"],"yoast_head":"\nONCO\/Reveal\u2122 Lung and Colon Cancer Genetic Test | Asia Molecular Diagnostics Laboratory Limited (AMDL) \u4e9e\u6d32\u5206\u5b50\u8a3a\u65b7\u5be6\u9a57\u5ba4\u6709\u9650\u516c\u53f8 | \u9999\u6e2f Hong Kong<\/title>\n<meta name=\"description\" content=\"Asia Molecular Diagnostic Laboratory Limited (AMDL) \u4e9e\u6d32\u5206\u5b50\u8a3a\u65b7\u5be6\u9a57\u5ba4\u6709\u9650\u516c\u53f8 is a molecular diagnostic laboratory in Hong Kong. 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