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Break the genetic code and accelerate research

AMDL’s platform is helping health systems and research institutions accelerate the integration of genomics into clinical care.

售前諮詢

Customer Registration

Sample Collection

Sample delivery

Test and Analysis

Reporting

ONCO/Reveal™ Dx Lung and Colon Cancer Assay

The ONCO/RevealTM Dx Lung and Colon Cancer Assay (oRDX-LCCA) is a qualitative next generation sequencing based in vitro diagnostic test that uses amplicon-based target enrichment technology for detection of single nucleotide variants (SNVs) and deletions in 2 genes from DNA isolated from formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) tumor tissue specimens. The test is intended as a companion diagnostic to identify patients with NSCLC or CRC who may benefit from treatment with the targeted therapeutics listed in Table 1 in accordance with the approved therapeutic product labeling. The oRDX-LCCA is intended to be used on the Illumina MiSeqDx® instrument.

ampPD™

ampPDTM assay design

• AI-enabled

• Automated

• Ultra-high plex 

SLIMamp®
Stem-Loop Inhibition-Mediated amplification (SLIMamp®) enrichment chemistry
  • Single tube library preparation with fully automation
  • Preventing nonspecific amplification in highly multiplexed PCR reactions
  • Decreasing contamination risks
  • Minimizing the amount of required input DNA to just 10 ng
  • Very low assay failure rate
PiVAT™

PiVATTM analysis platform

• Effective mutation detection
• Reduced sequencing errors
• Compatible with damaged FFPE samples

ampPD™

Intelligent primer design platform

Target Preparation
  • Perform tuneable masking for multi-copy regions, repeats and variants.

  • Delineate regions of interest (ROI) and collapse proximal ROIs.
Primer drafting and tiling

  • Exhaustively calculate all primer tiling solutions for each ROI.

  • Select primers that are optimized for FFPE samples.

Target Preparation

  • Calculate potential amplifiable pairs via cluster-based computing.

  • Compute single pool with the lowest dimer potential

SLIMamp®

Library preparation

PiVAT™

Bioinformatics pipeline

PiVAT Bioinformatics Workflow

Align to genome

Local realignment, filtering and read assembly

Proprietary variant calling

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