Our Platform

Break the genetic code and accelerate research

AMDL’s platform is helping health systems and research institutions accelerate the integration of genomics into clinical care.

Pre-sales consultation

Customer Registration

Sample Collection

Sample delivery

Test and Analysis

Reporting

ONCO/Reveal™ Dx Lung and Colon Cancer Assay

The ONCO/RevealTM Dx Lung and Colon Cancer Assay (oRDX-LCCA) is a qualitative next generation sequencing based in vitro diagnostic test that uses amplicon-based target enrichment technology for detection of single nucleotide variants (SNVs) and deletions in 2 genes from DNA isolated from formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) tumor tissue specimens. The test is intended as a companion diagnostic to identify patients with NSCLC or CRC who may benefit from treatment with the targeted therapeutics listed in Table 1 in accordance with the approved therapeutic product labeling. The oRDX-LCCA is intended to be used on the Illumina MiSeqDx® instrument.

ampPD™

ampPDTM assay design

• AI-enabled

• Automated

• Ultra-high plex 

SLIMamp®
Stem-Loop Inhibition-Mediated amplification (SLIMamp®) enrichment chemistry
  • Single tube library preparation with fully automation
  • Preventing nonspecific amplification in highly multiplexed PCR reactions
  • Decreasing contamination risks
  • Minimizing the amount of required input DNA to just 10 ng
  • Very low assay failure rate
PiVAT™

PiVATTM analysis platform

• Effective mutation detection
• Reduced sequencing errors
• Compatible with damaged FFPE samples

ampPD™

Intelligent primer design platform

Target Preparation
  • Perform tuneable masking for multi-copy regions, repeats and variants.

  • Delineate regions of interest (ROI) and collapse proximal ROIs.
Primer drafting and tiling

  • Exhaustively calculate all primer tiling solutions for each ROI.

  • Select primers that are optimized for FFPE samples.

Target Preparation

  • Calculate potential amplifiable pairs via cluster-based computing.

  • Compute single pool with the lowest dimer potential

SLIMamp®

Library preparation

PiVAT™

Bioinformatics pipeline

PiVAT Bioinformatics Workflow

Align to genome

Local realignment, filtering and read assembly

Proprietary variant calling

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