ONCO/Reveal™
Solid Tumor Genetic Test

What is Solid Tumor Genetic Test?

It detects numerous, relevant gene regions of interest for researchers looking to explore the genetic sequences of both germline and formalin-fixed paraffin-embedded (FFPE) DNA samples from solid tumor samples. The panel utilizes Pillar Biosciences’ proprietary SLIMamp® (stem-loop inhibition mediated amplification) technology, allowing researchers to amplify regions of interest in a simple, multiplex reaction for subsequent sequencing on a sequencer using a paired-end read length of 150 (2×150).

In 2020, Asia reported the most outrageous number of new cancer cases and death worldwide. According to global data conducted by World Health Organization, approximately 9 million of new cases were diagnosed respectively among Asian, together with 5 million deaths.

Reduction of mortality from a specific cancer can be achieved by early cancer screening and diagnosis. With the next generation sequencing (NGS) technique, it holds the promise of detecting tumour mutations on either tumour cells or free circulating tumour DNA in a comprehensive and concise way for physicians to select appropriate targeted therapeutical drugs for cancer treatment. An early diagnosis opens the door to future care and cancer treatment, increasing the overall survival rate.

Target

Researchers looking to explore the genetic sequences of both germline and formalin-fixed paraffin-embedded (FFPE) DNA from solid tumour samples.

Table 1: Gene List

AKT1 DDR2 FGFR2 HRAS NRAS PTEN SRSF2
ALK EGFR FGFR3 IDH1 NTRK1 PTPN11 STK11
ARAF EIF1AX GNA11 IDH2 PDGFRA RAC1 TERT
BRAF ERBB2 GNAQ KIT PIK3CA RAF1 TP53
CDKN2A ERBB4 GNAS KRAS PLCB4 RET TSHR
CTNNB1 FBXW7 H3F3A MAP2K1 POLD1 SF3B1
CYSLTR2 FGFR1 HIST1H3B MET POLE SMAD4

Table 1: Gene List

AKT1 DDR2 FGFR2 HRAS NRAS
PTEN SRSF2 ALK EGFR FGFR3
IDH1 NTRK1 PTPN11 STK11 ARAF
PIK3CA RAF1 TP53 CDKN2A ERBB4
CTNNB1 FBXW7 H3F3A MAP2K1 POLD1
SF3B1 CYSLTR2 FGFR1 HIST1H3B MET
POLE SMAD4
AKT1
Solid Tumor Genetic Test
Content
47 genes detected from solid tumour (please refer to table 1 for details)
Sequencing Platform
NGS
Sequencing Type
Amplicon based sequencing
Variants Type
SNVs, indel and medium indels
Sample Type
FFPE
TAT
7 working days**

Workflow

STEP 01
STEP 01

Pre-sales consultation

STEP 02
STEP 02

Sign the consent form, collect paraffin-embedded sections

STEP 03
STEP 03

Send the specimen to the laboratory

STEP 04
STEP 04

Analyse the experimental data

STEP 05
STEP 05

A total of 7 working days to complete the report**

**Only applicable to the sample that fulfil the QC requirements.

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